HS-LS3.A: Inheritance of Traits
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DNA Replication Worksheet Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Worksheet
Students answer questions about DNA replication and label a model of DNA replication.NGSS Standard
HS-LS1-4
HS-LS3-1
Published by NGSS Life Science
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DNA Structure Worksheet Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Worksheet
Students answer questions about DNA’s structure, genetic code is the nitrogen base sequence, complimentary base pairing, and DNA replication.NGSS Standard
HS-LS3-1
Published by NGSS Life Science
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DNA and Chromosomes Test Question Bank Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Test
DNA and Chromosome question bank to help you build assessments. An active membership is required to view questions.NGSS Standard
HS-LS3-1
Published by NGSS Life Science
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BLAST Cancer RAS Gene Project Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Project
Students will do a BLAST and learn about how a mutated gene will code for an abnormal protein, affecting the organism’s phenotype.NGSS Standard
HS-LS1-1
HS-LS1-4
HS-LS3-1
HS-LS3-2
HS-LS4-1
Published by NGSS Life Science
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Meiosis Worksheet - Linked Genes Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Worksheet
In this advanced meiosis worksheet, students will practice citing evidence of gene linkage using crossover frequencies to defend a claim.NGSS Standard
HS-LS3-1
HS-LS3-2
Published by NGSS Life Science
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Protein Synthesis Test Question Bank Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Test
Question bank to build assessments. An active membership is required to view questions.NGSS Standard
HS-LS1-1
Published by NGSS Life Science
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Recombinant Paper Plasmids Free Lesson Plan
Free Video
Lab
Biomedical engineers use recombinant DNA technologies with the goal of curing genetic diseases & cancer, and to improve agricultural yields. Students will model several of the steps of restriction enzymes to build plamids.NGSS Standard
HS-LS3-1
Published by Ely Science Center
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Strawberry DNA Extraction Lab Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Lab
Students will extract DNA from both bananas and strawberries. This is a great lab to do while introducing biomolecules for nucleic acids.NGSS Standard
HS-LS3-1
Published by NGSS Life Science
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Cracking the Code of Life Free Video
Multimedia
This NOVA video covers topics including the human genome, mutations, genetic variations, the supreme court decision to patent genes, finding cures to diseases, and genetic modification.NGSS Standard
HS-LS3-1
Published by WGBH Educational Foundation and Clear Blue Sky Productions
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Genetic Ethics Questions Free Lesson Plan
Worksheet
Students answer multiple choice questions on science ethics relating to genetics (cloning, gene therapy). The class then discusses the pros and cons of each of the questions.NGSS Standard
HS-LS3-1
Published by Shannan Muskopf
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Transcription and Translation Lab - From Gene to Protein Free Student Handout
Free Teacher Notes
Lab
In this transcription and translation lab, students learn how a gene provides the instructions for making a protein, and how a mutation in the gene for sickle cell hemoglobin can result in sickle cell anemia. Students use paper models to transcribe and translate the DNA into a protein.NGSS Standard
HS-LS1-1
HS-LS3-1
HS-LS3-2
MS-LS3-1 (Mutations)
Published by Ingrid Waldron and Jennifer Doherty
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DNA Extraction Lab Free Student Handout
Free Teacher Notes
Lab
In this DNA lab, students extract DNA from their cheek cells to learn about the structure of DNA and DNA replication. The lab has students think about why they were using each reagent and how that relates to the polarity of lipids. Students answer questions regarding DNA base pairing and it relates to the central dogma (DNA - Proteins - Traits).NGSS Standard
HS-LS1-1
HS-LS3-1
Published by Ingrid Waldron and Jennifer Doherty
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Chromosome Modeling Lab - Mitosis, Meiosis and Fertilization Free Student Handout
Free Teacher Notes
Lab
In this chromosome modeling lab, students create pairs of socks models of chromosomes to model the processes of mitosis, meiosis, and fertilization. Students also build a foundation about meiosis and fertilization and how it relates to genetics and genetic disorders.NGSS Standard
HS-LS1-4
HS-LS3-1
HS-LS3-2
Published by Ingrid Waldron and Jennifer Doherty
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DNA to Me Lyrics Project Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Project
In this protein synthesis project, students will write a poem or music lyrics about DNA, protein synthesis, and phenotypes. This DNA project is a culmination of what students who have already learned about DNA structure, DNA base pairing, genes, transcription, translation, and phenotypes.NGSS Standard
HS-LS1-1
HS-LS1-6
HS-LS3-1
Published by NGSS Life Science
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Bacteria Transformation Free Lesson Plan
Lab
Students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria. They learn what role restriction enzymes, DNA ligase, and genes play in the modification of organisms. This activity will use the insulin gene and combine it with a bacteria's gene sequence (plasmid DNA) for the production of the protein insulin for medicine.NGSS Standard
HS-LS3-1
Published by Teach Engineering
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Gene Expression - Ghost in Your Genes Free Lesson Plan
Free Video
Lab
Students model how scientists use DNA microarrays to determine levels of gene expression in breast cancer patients, and then choose treatments based on what they learn.NGSS Standard
HS-LS1-1
HS-LS3-1
Published by Margy Kuntz and NOVA / PBS
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DNA Fingerprinting Crime Scene Free Lesson Plan
Worksheet
Students will examine crime scene evidence to determine who is responsible for eating the Queen's special imported Lindbergher Cheese. Students will model the process of electrophoresis and DNA fingerprinting.NGSS Standard
HS-LS3-1
Published by Shannan Muskopf
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DNA Structure Quiz Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Test
With this DNA structure quiz, students’ knowledge of the structure of DNA is assessed. Topics include double helix, nucleotide monomers, DNA polymers, nucleic acids biomolecules, DNA replication, complementary strands and base pairing, deoxyribose sugar and phosphate backbone, and nitrogen bases, adenine, guanine, cytosine, thymine.NGSS Standard
HS-LS1-6
HS-LS3-1
Published by NGSS Life Science
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Diploid vs Haploid Worksheet Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Worksheet
In this meiosis chromosome worksheet, students answer questions about the number of chromosomes generated by either mitosis or meiosis. Haploid and diploid chromosome numbers help students understand the reproduction type used in each process.NGSS Standard
HS-LS1-4
HS-LS3-1
HS-LS3-2
MS-LS3-2 (Types of Reproduction)
Published by NGSS Life Science
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Double Helix Modeling Lab Free Lesson Plan (PDF)
Lesson Plan (DOCX) & Answer Key with Membership
Lab
In this DNA modeling lab, students build a paper model of the double helix. Students label the DNA molecule with the four DNA nucleotides and practice nitrogen base paring. At the end of class, students can attach all the models and twist and coil them to simulate super coiling.NGSS Standard
HS-LS3-1
Published by NGSS Life Science